Food alters the QTc and might be an attractive non-pharmacological method of confirming assay sensitivity in Thorough QT (TQT) studies. This idea was recently examined (Taubel et al., 2011) and showed that food shortens QTcF. This is important because previously it has been debated in the literature to whether euglycaemic hyperinsulinemia can prolong the QTc interval (Gastaldelli et al. 2000).The European Congress of Pharmacology will be hosted this year by the Spanish Society of Pharmacology in Granada, Spain from 17-20 July, and will bring together pharmacologists from all over the world to debate current drug research and development issues from �bench to bedside�.Following Dr Taubel�s presentation  at the DIA 3rd Cardiac Safety Workshop in Japan, he will present his latest data assessing how late changes  i.e. 2-4 hours after the end of a euglycaemic insulin clamp can lead to significant increases in QTcF in healthy subjects. The presentation will be based on a single centre, randomised, placebo- and positive-controlled study that was carried out by Richmond Pharmacology in both healthy Caucasian and Japanese subjects. The euglycaemic insulin clamp was used to investigate the effects of insulin, C-peptide and glucose on the QT interval.View the Scientific Program

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Events

JPW2022 (Japan Basic and Clinical Pharmacology Week 2022)

30 November – 3 December 2022
This event will be the 96th Annual Meeting of the Japanese Pharmacological Society and the 43rd Annual Meeting of the Japanese Society of Clinical Pharmacology. 
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