Food alters the QTc and might be an attractive non-pharmacological method of confirming assay sensitivity in Thorough QT (TQT) studies. This idea was recently examined (Taubel et al., 2011) and showed that food shortens QTcF. This is important because previously it has been debated in the literature to whether euglycaemic hyperinsulinemia can prolong the QTc interval (Gastaldelli et al. 2000).The European Congress of Pharmacology will be hosted this year by the Spanish Society of Pharmacology in Granada, Spain from 17-20 July, and will bring together pharmacologists from all over the world to debate current drug research and development issues from �bench to bedside�.Following Dr Taubel�s presentation  at the DIA 3rd Cardiac Safety Workshop in Japan, he will present his latest data assessing how late changes  i.e. 2-4 hours after the end of a euglycaemic insulin clamp can lead to significant increases in QTcF in healthy subjects. The presentation will be based on a single centre, randomised, placebo- and positive-controlled study that was carried out by Richmond Pharmacology in both healthy Caucasian and Japanese subjects. The euglycaemic insulin clamp was used to investigate the effects of insulin, C-peptide and glucose on the QT interval.View the Scientific Program

Latest news

Futureproofing early phase clinical research for the next generation of investigators.

March 20, 2023
Richmond Pharmacology’s experienced Principal investigators and Co-investigators recently gave expert feedback on the ICH M11 (CeSHarP) protocol template.
Read more

Director of Operations, Keith Berelowitz, has been appointed as the Research Ethics Committee Chair for the Health Research Authority.

January 19, 2023
Keith Berelowitz will be responsible for ensuring that all ethical possibilities are explored in relation to new research.
Read more

Events

13th International Workshop on Regulatory Requirements and Current Scientific Aspects on the Preclinical and Clinical Investigation of Drug-Drug Interactions

Sunday, June 4th to Tuesday June 6th 2023
Exchange research-based knowledge on drug-drug interactions (DDIs) among all interested stakeholders from pharmaceutical industry, regulatory authorities, academic and health care delivery backgrounds and perspectives.
View event