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Cardiac Safety

Sex Hormones and the QT Interval
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Sex differences in subinterval measurements
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The differences between two algorithms
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Do hERG blocking agents further increase
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Concentration-QTC Analysis of a Cholinomimetic Agent
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Influence of calcium blockade on the QT effects of a meal
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Confirmation of the Cardiac Safety of PGF2α Receptor Antagonist
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Diurnal Profile of the QTc Interval
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The cardiovascular effects of a meal
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A Phase I study to investigate the effects of Clascoterone on QT interval
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Confirmation of the Cardiac Safety of P218
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Assessment of C-Peptide Effects on Cardiac Ion Channel Currents
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Comparison of ECG Parameters Using GE Getemed Continuous ECG Holter and MAC-1200 Bedside ECG
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Cardiac Safety of Rupatadine in a Single-Ascending-Dose and Multiple-Ascending-Dose
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Estimation of the Power of the Food Effect on QTc
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Confirmation of the Cardiac Safety of OBE022
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The 24 Hour Profile of Moxifloxacin Effect on QTc
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QT prolongation in healthy Japanese subjects
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Sex differences on the effect of moxifloxacin
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Alternative methods for the confirmation of assay sensitivity in Thorough QT studies
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Retrospective analysis of ECG data
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Moxifloxacin effect on QTc interval
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The Impact of Insulin Levels on QTc Interval in Thorough QT Studies
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Retrospective Validation using PK-PD modelling of ECG data
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Comparison of digital 12-lead ECG and digital 12-lead holter ECG
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Late Changes After a Euglycaemic Insulin Clamp
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Confirmation of the Cardiac Safety of Rupatadine in a Single Ascending Dose and Multiple Ascending Dose
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Investigating the effect of intravenous APD421 (Amilsulpride) and the ethnic differences
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The Power Of Phase I Studies To Detect Clinically Relevant Qtc Prolongation
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Repeated supratherapeutic dosing of strontium ranelate
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Insulin at normal physiological levels does not prolong QTc interval
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Lamotrigine does not prolong QTc in TQT studies
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Thorough QT study of the effect of oral moxifloxacin on QTc interval
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Mason-Likar electrode configuration
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Investigating the Ethnic Differences between the Effect of Moxifloxacin on Cardiac Conduction
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Comparison of Six Commonly Used QT Correction Models and Their Parameter Estimation Methods
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Shortening of the QT Interval After Food
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Levofloxacin can be used as a positive control in QT/QTc
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Bupivacaine Extended Release Liposome Injection
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Comparison of the effects of levofloxacin on QT/QTc interval
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Analyzing the Relationship of QT Interval and Exposure to Nitazoxanide
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Concentration-Effect Modeling Based on Change From Baseline
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Single Doses up to 800 mg of E-52862
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Assay Sensitivity in QT Assessment
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Do hERG blocking agents further increase the risk of sudden cardiac death in patients with type 1 diabetes?
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Effects of progesterone and estradiol on QT subintervals over the course of a menstrual cycle
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Meta-analysis of the effect of a meal on QTcF
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CRISPR-Cas9 in-vivo gene editing shows reduction in TTR after a single dose
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Practical Risk Management
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Pharmacokinetics and Safety of the Oral Prostaglandin F2 alpha Receptor Antagonist OBE022
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The Pharmacokinetic Interaction of the Selective PGF2α Receptor Antagonist OBE022
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Efficient Design of Integrated and Adaptively Interlinked
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Clinical Trials
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The pharmacokinetic interaction between isoniazid/pyrazinamide and TMC207
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PET500 A Newly Formulated Tetracaine Product
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Analysis of safety, pharmacokinetic and pharmacodynamic data
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No clinically relevant effect of TMC125 on the pharmacokinetics
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A phase I, randomised single center, open-label parallel group trial to compare the pharmacokinetics
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The influence of a low fat diet and hospitalisation on liver function tests
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How adaptive study design
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Ascending single-dose study with ACT-280778, a non-dihydropyridine, dual L- and T-type calcium channel blocker
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Effects on 24-Hour Intragastric pH
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Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab)
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Cizolirtine Citrate (E-4018) in the Treatment of Chronic Neuropathic Pain
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Rule Britannia – the advantages of conducting first-time-in-human (FTIH) studies in the UK
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The practical application of adaptive study design in early phase clinical trials
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Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164
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Early phase clinical trials in the United Kingdom
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Three steps to writing adaptive study protocols
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The safety, tolerability and pharmacokinetics of AZD5069, a novel CXCR2 antagonist
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Similar Rivastigmine Pharmacokinetics and Pharmacodynamics
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Gastric Acid Suppression Effect of TAK-438, A Potassium-Competitive Acid Blocker
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Pharmacokinetics and tolerability of sublingual fentanyl
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Gastric Acid Suppression Effect of TAK-438, A Potassium-Competitive Acid Blocker
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Pharmacokinetics, Safety and Tolerability of Rupatadine
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Early Phase Japanese Bridging Studies
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Lomitapide single-and multiple-dose exposure
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Diurnal and Racial Variance of White Blood Cell Parameters
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Occult Hepatic Steatosis
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Concentration-Effect Modelling of Blood-Pressure
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Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction
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An open-label, parallel-group, repeat-dose study
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Effect of oseltamivir treatment on anticoagulation
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Benefits of a Single Versus Multicenter Approach in Early-Phase Patient Studies
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