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Cardiac Safety
Clinical Pharmacology & Adaptive Early Phase Studies
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Cardiac Safety

Sex Hormones and the QT Interval

Sex Hormones and the QT Interval

Sex Hormones and the QT Interval: J‐Tpeak and Tpeak‐Tend Assessment and Further Insights Into the Physiological Effects.

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Sex differences in subinterval measurements

Sex differences in subinterval measurements

Sex differences in subinterval measurements in intervention-free, fasted ECGs from seven intensive QT studies.

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The differences between two algorithms

The differences between two algorithms

The differences between two algorithms used to measure ECG subintervals in intervention-free, fasted volunteers taking part in an intensive QT study.

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Do hERG blocking agents further increase

Do hERG blocking agents further increase

Do hERG blocking agents further increase the risk of sudden cardiac death in patients with type 1 diabetes?

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Concentration-QTC Analysis of a Cholinomimetic Agent

Concentration-QTC Analysis of a Cholinomimetic Agent

Concentration-QTC Analysis of a Cholinomimetic Agent Integrated into a Phase 1 – Japanese Bridging Study Using Intensive ECG Assessments

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Influence of calcium blockade on the QT effects of a meal

Influence of calcium blockade on the QT effects of a meal

Influence of calcium blockade on the QT effects of a meal – Food ingestion in healthy volunteers leads to an increase in heart rate cardiac stroke volume.

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Confirmation of the Cardiac Safety of PGF2α Receptor Antagonist

Confirmation of the Cardiac Safety of PGF2α Receptor Antagonist

Confirmation of the Cardiac Safety of PGF2α Receptor Antagonist in a First-In-Human Study in Healthy Subjects, Using Intensive ECG Assessments.

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Diurnal Profile of the QTc Interval

Diurnal Profile of the QTc Interval

Diurnal Profile of the QTc Interval Following Moxifloxacin Administration | J. Täubel , G. Ferber, S. Fernandes, A. John Camm.

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The cardiovascular effects of a meal

The cardiovascular effects of a meal

The cardiovascular effects of a meal: assessment of the effects on J-Tpeak and Tpeak-Tend intervals

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A Phase I study to investigate the effects of Clascoterone on QT interval

A Phase I study to investigate the effects of Clascoterone on QT interval

A Phase I study to investigate the effects of Clascoterone on QT interval using the effects of a meal on QTc to demonstrate ECG assay sensitivity

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Confirmation of the Cardiac Safety of P218

Confirmation of the Cardiac Safety of P218

Confirmation of the Cardiac Safety of P218, a new Investigational Medicinal Product for Prevention of Malaria using Intensive ECG Assessments and the Effect of a Meal on QTC to show Assay Sensitivity.

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Assessment of C-Peptide Effects on Cardiac Ion Channel Currents

Assessment of C-Peptide Effects on Cardiac Ion Channel Currents

Assessment of C-Peptide Effects on Cardiac Ion Channel Currents. J. Täubel, G. Ferber, Teresa del Bianco, S. Fernandes, Dilshat Djumanov, A. John Camm.

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Comparison of ECG Parameters Using GE Getemed Continuous ECG Holter and MAC-1200 Bedside ECG

Comparison of ECG Parameters Using GE Getemed Continuous ECG Holter and MAC-1200 Bedside ECG

Comparison of ECG Parameters Using GE Getemed Continuous ECG Holter and MAC-1200 Bedside ECG. Jörg Täubel, Teresa Del Bianco, Sara Fernandes, Boaz Mendzelevski, Dilshat Djumanov, George Ferber.

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Cardiac Safety of Rupatadine in a Single-Ascending-Dose and Multiple-Ascending-Dose

Cardiac Safety of Rupatadine in a Single-Ascending-Dose and Multiple-Ascending-Dose

Cardiac Safety of Rupatadine in a Single-Ascending-Dose and Multiple-Ascending-Dose Study in Healthy Japanese Subjects, Using Intensive Electrocardiogram Assessments – Comparison With the Previous White Caucasian Thorough QT Study

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Estimation of the Power of the Food Effect on QTc

Estimation of the Power of the Food Effect on QTc

Estimation of the Power of the Food Effect on QTc to Show Assay Sensitivity. Georg Ferber, PhD, Sara Fernandes, PhD, and Jörg Täubel,MD, FFPM.

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Confirmation of the Cardiac Safety of OBE022

Confirmation of the Cardiac Safety of OBE022

Confirmation of the Cardiac Safety of OBE022 in a First in Human Study in Healthy Subjects using Intensive ECG Assessments and the Effect of a Meal on QTc to Show Assay Sensitivity – One of the objectives of this first-in-human study was

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The 24 Hour Profile of Moxifloxacin Effect on QTc

The 24 Hour Profile of Moxifloxacin Effect on QTc

The 24 Hour Profile of Moxifloxacin Effect on QTc – A Reflection of Diurnal Variations – This study aims to define the time course of the effect of moxifloxacin on the QT-interval with continuous Holter data in order to better understand

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QT prolongation in healthy Japanese subjects

QT prolongation in healthy Japanese subjects

QT prolongation in healthy Japanese subjects receiving moxifloxacin in Thorough QT studies. Taubel et al. The 32nd Annual Meeting of The Japanese Society of Clinical Pharmacology and Therapeutics (JSCPT), 1-3 December 2011, Tokyo, Japan. Program

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Sex differences on the effect of moxifloxacin

Sex differences on the effect of moxifloxacin

Sex differences on the effect of moxifloxacin – A meta-analysis of five Thorough QT Studies. Taubel et al. The 32nd Annual Meeting of The Japanese Society of Clinical Pharmacology and Therapeutics (JSCPT), 1-3 December 2011, Tokyo, Japan.

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Alternative methods for the confirmation of assay sensitivity in Thorough QT studies

Alternative methods for the confirmation of assay sensitivity in Thorough QT studies

Alternative methods for the confirmation of assay sensitivity in Thorough QT studies. Taubel et al. The 32nd Annual Meeting of The Japanese Society of Clinical Pharmacology and Therapeutics (JSCPT), 1-3 December 2011, Tokyo, Japan. Program

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Retrospective analysis of ECG data

Retrospective analysis of ECG data

Retrospective analysis of ECG data derived from a four-way cross over study involving a broad spectrum anti-infective agent nitazoxanide. Taubel et al. Pharmacology 2013, London, UK, 17-19 December 2013

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Moxifloxacin effect on QTc interval

Moxifloxacin effect on QTc interval

Moxifloxacin effect on QTc interval in the fed and fasted states in Thorough QT studies. Jorg Taubel MD FFPM. DIA/FDA Cardiovascular Safety in Drug Development: State-of-the-art Assessments, Washington 18th April 2012

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The Impact of Insulin Levels on QTc Interval in Thorough QT Studies

The Impact of Insulin Levels on QTc Interval in Thorough QT Studies

The Impact of Insulin Levels on QTc Interval in Thorough QT Studies Conducted in Healthy Subjects. Taubel et al. ACCP Annual Meeting, San Diego 23-25 September 2012

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Retrospective Validation using PK-PD modelling of ECG data

Retrospective Validation using PK-PD modelling of ECG data

Retrospective Validation using PK-PD modelling of ECG data derived from a Single Ascending Dose study in accordance with the principles of the ICH E14 guideline utilising the effects of a Meal to establish assay sensitivity. 2013 Annual Meeting

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Comparison of digital 12-lead ECG and digital 12-lead holter ECG

Comparison of digital 12-lead ECG and digital 12-lead holter ECG

Comparison of digital 12-lead ECG and digital 12-lead holter ECG recordings in health male subjects. 112th ASCPT Annual Meeting, March 2-5, 2011, Dallas, TX. Poster Number: PI-08, scheduled on 3/3/2011 from 8:00 AM.

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Late Changes After a Euglycaemic Insulin Clamp

Late Changes After a Euglycaemic Insulin Clamp

Late Changes After a Euglycaemic Insulin Clamp Can Lead to Significant Increases in QTcF In Healthy Subjects. Taubel et al. 2012 ACCP Annual Meeting, San Diego 23-25 September 2012

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Confirmation of the Cardiac Safety of Rupatadine in a Single Ascending Dose and Multiple Ascending Dose

Confirmation of the Cardiac Safety of Rupatadine in a Single Ascending Dose and Multiple Ascending Dose

Confirmation of the Cardiac Safety of Rupatadine in a Single Ascending Dose and Multiple Ascending Dose Study in Japanese Healthy Subjects Using Intensive ECG Assessments. Jorg Taubel · Georg Ferber · Inaki Izuierdo. 2015 Annual Meeting, San

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Investigating the effect of intravenous APD421 (Amilsulpride) and the ethnic differences

Investigating the effect of intravenous APD421 (Amilsulpride) and the ethnic differences

Investigating the effect of intravenous APD421 (Amilsulpride) and the ethnic differences between Japanese and Caucasians on cardiac conduction. Jorg Taubel · Georg Ferber · Gabriel Fox · Sara Fernandes · Ulrike Lorch · A John Camm. Tokyo, The

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The Power Of Phase I Studies To Detect Clinically Relevant Qtc Prolongation

The Power Of Phase I Studies To Detect Clinically Relevant Qtc Prolongation

The Power Of Phase I Studies To Detect Clinically Relevant Qtc Prolongation – Results From A Resampling Simulation Study. Ferber et al. The 35th Annual Meeting of The Japanese Society of Clinical Pharmacology and Therapeutics (JSCPT), 4-6

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Repeated supratherapeutic dosing of strontium ranelate

Repeated supratherapeutic dosing of strontium ranelate

Repeated supratherapeutic dosing of strontium ranelate over 15 days does not prolong QTc interval in healthy volunteers. Taubel et al. Br J Clin Pharmacol 2012;74(2): 296-303

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Insulin at normal physiological levels does not prolong QTc interval

Insulin at normal physiological levels does not prolong QTc interval

Insulin at normal physiological levels does not prolong QTc interval in thorough QT studies performed in healthy volunteers. Taubel et al. Br J Clin Pharmacol 2012;75(2): 392-403

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Lamotrigine does not prolong QTc in TQT studies

Lamotrigine does not prolong QTc in TQT studies

Lamotrigine does not prolong QTc in TQT studies in healthy subjects. Dixon R et al. Br J Clin Pharmacol 2008;66(3):396-404

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Thorough QT study of the effect of oral moxifloxacin on QTc interval

Thorough QT study of the effect of oral moxifloxacin on QTc interval

Thorough QT study of the effect of oral moxifloxacin on QTc interval in the fed and fasted state in healthy Japanese and Caucasian subjects. Taubel J et al. Br J Clin Pharmacol 2014;77 (1), 170-179

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Mason-Likar electrode configuration

Mason-Likar electrode configuration

Mason-Likar electrode configuration can confound the recognition of electrode cable interchange. Velislav N et al. J Electrocard, 2010.12.164

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Investigating the Ethnic Differences between the Effect of Moxifloxacin on Cardiac Conduction

Investigating the Ethnic Differences between the Effect of Moxifloxacin on Cardiac Conduction

Investigating the Ethnic Differences between the Effect of Moxifloxacin on Cardiac Conduction in Japanese and Caucasians. Dr Jorg Taubel MD FFPM. 5th DIA Cardiac Safety Workshop in Japan, 24 October 2014, Tokyo, Japan

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Comparison of Six Commonly Used QT Correction Models and Their Parameter Estimation Methods

Comparison of Six Commonly Used QT Correction Models and Their Parameter Estimation Methods

Comparison of Six Commonly Used QT Correction Models and Their Parameter Estimation Methods. Wang et al. Journal of Biopharmaceutical Statistics 2012; 22(6):1148-1161

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Shortening of the QT Interval After Food

Shortening of the QT Interval After Food

Shortening of the QT Interval After Food Can Be Used to Demonstrate Assay Sensitivity in Thorough QT Studies. Taubel et al. J Clin Pharmacol, 2012;52:1558-1565

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Levofloxacin can be used as a positive control in QT/QTc

Levofloxacin can be used as a positive control in QT/QTc

Levofloxacin can be used as a positive control in QT/QTc studies in healthy subjects (paper). Taubel J et al. Br J Clin Pharmacol 2010;69(4):391-400

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Bupivacaine Extended Release Liposome Injection

Bupivacaine Extended Release Liposome Injection

Bupivacaine Extended Release Liposome Injection Does Not Prolong QTc Interval in a Thorough QT/QTc Study in Healthy Volunteers. Naseem et al. J Clin Pharmacol, 2012;52:1441-1447

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Comparison of the effects of levofloxacin on QT/QTc interval

Comparison of the effects of levofloxacin on QT/QTc interval

Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects. Sugiyama et al. Br J Clin Pharmacol 2011;73(3): 455-459

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Analyzing the Relationship of QT Interval and Exposure to Nitazoxanide

Analyzing the Relationship of QT Interval and Exposure to Nitazoxanide

Analyzing the Relationship of QT Interval and Exposure to Nitazoxanide, a Prospective Candidate for Influenza Antiviral Therapy – A Formal TQT Study. Taubel et al. J Clin Pharmacol, 2014. Submitted for publication 24 February 2014;

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Concentration-Effect Modeling Based on Change From Baseline

Concentration-Effect Modeling Based on Change From Baseline

Concentration-Effect Modeling Based on Change From Baseline to Assess the Prolonging Effect of Drugs on QTc Together With an Estimate of the Circadian Time Course. Ferber et al. J Clin Pharmacol, 2014. Submitted for publication 3 April 2014;

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Single Doses up to 800 mg of E-52862

Single Doses up to 800 mg of E-52862

Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval – A Retrospective Validation by Pharmacokinetic- Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay

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Assay Sensitivity in QT Assessment

Assay Sensitivity in QT Assessment

Assay Sensitivity in QT Assessment. Taubel J et al. Journal for Clinical Studies 2015, 7(6): 60-62

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Do hERG blocking agents further increase the risk of sudden cardiac death in patients with type 1 diabetes?

Do hERG blocking agents further increase the risk of sudden cardiac death in patients with type 1 diabetes?

The data from this study suggest that QT prolonging drugs should be administered with caution to type 1 diabetic patients.

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Effects of progesterone and estradiol on QT subintervals over the course of a menstrual cycle

Effects of progesterone and estradiol on QT subintervals over the course of a menstrual cycle

This study aimed to assess whether there is a reliable evidence for the influence of a menstrual cycle on the duration of cardiac subintervals.

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Meta-analysis of the effect of a meal on QTcF

Meta-analysis of the effect of a meal on QTcF

In this meta-analysis, 12 separate thorough QT studies conducted at Richmond Pharmacology Ltd, London, UK were analysed alongside one another to observe the consistency of the effect of a meal on the QTc interval, and to observe any trends associated with sex.

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CRISPR-Cas9 in-vivo gene editing shows reduction in TTR after a single dose

CRISPR-Cas9 in-vivo gene editing shows reduction in TTR after a single dose

Data produced through and Intellia Therapeutic’s NTLA-2001 FIH clinical trial, conducted at Richmond Pharmacology, indicates a reduction in the faulty TTR protein after a single infusion. Results were presented by Professor Julian Gillmore at this year’s Peripheral Nerve Society Annual Meeting

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Clinical Pharmacology and Adaptive Early Phase Studies

Practical Risk Management

Practical Risk Management for Adaptive Integrated Early Phase Clinical Trials Method.

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Pharmacokinetics and Safety of the Oral Prostaglandin F2 alpha Receptor Antagonist OBE022

Pharmacokinetics and Safety of the Oral Prostaglandin F2 alpha Receptor Antagonist OBE022: A First-In-Human Study in Healthy Post-Menopausal Women.

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The Pharmacokinetic Interaction of the Selective PGF2α Receptor Antagonist OBE022

The Pharmacokinetic Interaction of the Selective PGF2α Receptor Antagonist OBE022 on Co-Administration with MgSO4, Atosiban, Nifedipine or Betamethasone

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Efficient Design of Integrated and Adaptively Interlinked

Efficient Design of Integrated and Adaptively Interlinked Early Phase Drug Development Programmes.

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Clinical Trials

Clinical Trials: A Practical Guide to Design, Analysis, and Reporting Crossover Trials Bioequivalence Trials Source and Control of Bias

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The pharmacokinetic interaction between isoniazid/pyrazinamide and TMC207

The pharmacokinetic interaction between isoniazid/pyrazinamide and TMC207, an investigational antimycobacterial agent.

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PET500 A Newly Formulated Tetracaine Product

PET500 A Newly Formulated Tetracaine Product is Effective in Reducing Penile Sensitivity. Taube et al. Thirty-Ninth Annual Meeting American College of Clinical Pharmacology September 12-14, 2010 Baltimore, Maryland. J Clin Pharmacol, September

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Analysis of safety, pharmacokinetic and pharmacodynamic data

Analysis of safety, pharmacokinetic and pharmacodynamic data derived from a single ascending dose Phase 1 study involving a promising non-cytotoxic anti-cancer agent Sulforadex®. Taubel et al. Pharmacology 2013, London, UK, 17-19 December 2013

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No clinically relevant effect of TMC125 on the pharmacokinetics

No clinically relevant effect of TMC125 on the pharmacokinetics of oral contraceptives. Schöller-Gyüre M et al.

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A phase I, randomised single center, open-label parallel group trial to compare the pharmacokinetics

A phase I, randomised single center, open-label parallel group trial to compare the pharmacokinetics of NOMAC between healthy female adolescents (aged 14-17 years) and healthy female adults (aged 18-50 years) after single dose administration of

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The influence of a low fat diet and hospitalisation on liver function tests

The influence of a low fat diet and hospitalisation on liver function tests in healthy Japanese and Caucasian male volunteers resident in a Phase I unit for up to 34 days. 2013 Annual Meeting of the American College of Clinical Pharmacology

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How adaptive study design

How adaptive study design can enrich an early phase multiple ascending dose study. Lorch et al. 2014 Annual Meeting of the American College of Clinical Pharmacology (ACCP),Atlanta, GA , 14-16 September 2014

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Ascending single-dose study with ACT-280778, a non-dihydropyridine, dual L- and T-type calcium channel blocker

Ascending single-dose study with ACT-280778, a non-dihydropyridine, dual L- and T-type calcium channel blocker: safety, tolerability, pharmacokinetics, and effect of food in healthy male subjects. Mueller MS et al. Presented at the American

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Effects on 24-Hour Intragastric pH

Effects on 24-Hour Intragastric pH: A Comparison of Lansoprazole Administered Nasogastrically in Apple Juice and Pantoprazole Administered Intravenously. Freston J et al. The American Journal of Gastroenterology Vol. 96, No. 7, 2001

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Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab)

Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-inhuman study Zhenhua Xu et al. Br J Clin Pharmacol 2011 72(2) / 270-281

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Cizolirtine Citrate (E-4018) in the Treatment of Chronic Neuropathic Pain

Cizolirtine Citrate (E-4018) in the Treatment of Chronic Neuropathic Pain. Shembalkar P et al. Curr Med Res Opin 17(4):262-266, 2001

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Rule Britannia – the advantages of conducting first-time-in-human (FTIH) studies in the UK

Rule Britannia – the advantages of conducting first-time-in-human (FTIH) studies in the UK compared to other European markets. Taubel J, Berelowitz K, Lorch U. International Clinical Trials P16+ February 2011

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The practical application of adaptive study design in early phase clinical trials

The practical application of adaptive study design in early phase clinical trials: a retrospective analysis of time savings. Lorch et al. Eur J Clin Pharmacol (2012) 68:543-551

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Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164

Transient paradoxical bronchospasm associated with inhalation of the LAMA AZD9164: analysis of two Phase I, randomised, double-blind, placebo-controlled studies. Jorup et al. BMC Pulmonary Medicine 2014, 14:52

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Early phase clinical trials in the United Kingdom

Early phase clinical trials in the United Kingdom. Jorg Taubel, Richmond Pharmacology Ltd and David Rogers, Medicines Evaluation Unit Ltd, Wythenshawe Hospital.

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Three steps to writing adaptive study protocols

Three steps to writing adaptive study protocols in the early phase clinical development of new medicines. Lorch et al. BMC Medical Research Methodology 2014, 14:84 http://www.biomedcentral.com/1471-2288/14/84

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Japanese Studies

The safety, tolerability and pharmacokinetics of AZD5069, a novel CXCR2 antagonist

The safety, tolerability and pharmacokinetics of AZD5069, a novel CXCR2 antagonist,in healthy Japanese volunteers. Lorch et al. ERS 2012, September 1-5, Vienna, Austria

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Similar Rivastigmine Pharmacokinetics and Pharmacodynamics

Similar Rivastigmine Pharmacokinetics and Pharmacodynamics in Japanese and White Healthy Participants Following the Application of Novel Rivastigmine Patch. Lefèvre et al. J Clin Pharmacol April 2009 49: 430-443

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Gastric Acid Suppression Effect of TAK-438, A Potassium-Competitive Acid Blocker

Gastric Acid Suppression Effect of TAK-438, A Potassium-Competitive Acid Blocker Following Ascending Single Doses in Healthy Subjects. Sakurai et al. 20th United European Gastroenterology Week, Amsterdam, The Netherlands, 20-24 Oct 2012. GUT

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Pharmacokinetics and tolerability of sublingual fentanyl

Pharmacokinetics and tolerability of sublingual fentanyl in healthy Japanese and Caucasian volunteers: Phase I, open-label, single-dose study. Lorch U et al.

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Gastric Acid Suppression Effect of TAK-438, A Potassium-Competitive Acid Blocker

Gastric Acid Suppression Effect of TAK-438, A Potassium-Competitive Acid Blocker Following Ascending Multiple Doses in Healthy Subjects. Jenkins et al. 20th United European Gastroenterology Week, Amsterdam, The Netherlands, 20-24 Oct 2012. GUT

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Pharmacokinetics, Safety and Tolerability of Rupatadine

Pharmacokinetics, Safety and Tolerability of Rupatadine in Healthy Japanese Volunteers. Jorg Taubel · Eva Santamaria. 2015 Annual Meeting of the American College of Clinical Pharmacology, San Francisco, CA; 09/2015

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Early Phase Japanese Bridging Studies

Early Phase Japanese Bridging Studies; Their Global Significance and What to Look for when Selecting a Suitable Contract Research Organisation to Conduct these Studies. Berelowitz K et al. International Pharmaceutical Industry; Volume 3, Issue

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Lomitapide single-and multiple-dose exposure

Lomitapide single-and multiple-dose exposure in Japanese and Caucasian subjects: results of a Phase 1 pharmacokinetic and pharmacodynamic study. Taubel et al. The 46th Annual Scientific Meeting of the Japan Atherosclerosis Society, Tokyo, Japan,

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Patient Studies

Diurnal and Racial Variance of White Blood Cell Parameters

Diurnal and Racial Variance of White Blood Cell Parameters in Early Phase Clinical Trials: A Retrospective Analysis of Pooled Data from Multiple Phase I Trials

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Occult Hepatic Steatosis

Occult Hepatic Steatosis – How can we distinguish true treatment emerging liver signals from undetected, unrelated liver abnormalities?

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Concentration-Effect Modelling of Blood-Pressure

Concentration-Effect Modelling of Blood-Pressure in Early Stage Trials

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Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction

Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction: A Randomized Crossover Study

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An open-label, parallel-group, repeat-dose study

An open-label, parallel-group, repeat-dose study to investigate the effects of end-stage renal disease and haemodialysis on the pharmacokinetics of ropinirole. Tompson et al. 13th International Congress of Parkinson’s Disease and Movement

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Effect of oseltamivir treatment on anticoagulation

Effect of oseltamivir treatment on anticoagulation: a cross-over study in warfarinized patients. Davies B et al. Br J Clin Pharmacol 2010;70(6):834-843. Single centre drug interaction study in 20 patient volunteers on regular warfarin. The study

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Benefits of a Single Versus Multicenter Approach in Early-Phase Patient Studies

Benefits of a Single Versus Multicenter Approach in Early-Phase Patient Studies; A Case Study of Multiple Sclerosis Patients. Berelowitz et al. The Monitor Page 21-25. October 2011

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Pharmacodynamic Consequences of Administration of VLA-4 Antagonist CDP323 to Multiple Sclerosis Subjects

Pharmacodynamic Consequences of Administration of VLA-4 Antagonist CDP323 to Multiple Sclerosis Subjects: A Randomized, Double-Blind Phase 1/2 Study. Wolf et al. PLOS ONE Journal. March 2013 | Volume 8 | Issue 3 | e58438

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September 12, 2023
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Exciting Research Update: Enhancing Blinding in Clinical Trials with Auto-Injectors

September 5, 2023
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